Research Article
Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex
Table 1
The SERS peak assignments of chemicals listed in Figure
2.
| | | I | II | III | IV | V | | Chemical | Molecular structure | RS (cm−1) | Assignment | RS (cm−1) | Assignment | RS (cm−1) | Chemical | RS (cm−1) | Assignment | RS (cm−1) | Assignment |
| | Cysteine (Cys) [47–49] | | 665 | ν(C-S) | 837 | δ(HCS) | 1014 | δ(NCH) + δ(HCH) | 1156 | ν(C-O) + δ(NCH) | 1325 | δ(NCH) + δ(HCH) |
| | Homocysteine (Hcys) [47–49] | | 676 | ν(C-S) | 818 | δ(HCS) | 1004 | δ(NCH) + δ(HCH) | 1056 | δ(NCH) + δ(HCH) | 1137 | ν(C-O) + δ(NCH) |
| | γ-Glu-Cys [47, 49] | | 640 | ν(C-S) | 767 | δ(C-SH) | 842 | | 1068 | δ(NCH) + δ(HCH) | 1380 | |
| | Glutathione (GSH) [50] | | 663 | ν(C-S) | 835 | ν(C-CN) | 1022 | ν(C-N) | 1115 | ν(N-C) + ν(C-C) | 1414 | ν(OCO) |
| | Thiosalicylic acid (TSA) [51–53] | | 797 | ν(C-COOH) | 1035 | Ring breath | 1114 | | 1161 | δip(C-H) | 1578 | Ring stretch |
| | 2-Naphthalenethiol (2-NT) [54] | | 768 | | 845 | (C-H) | 1064 | δ(C-H) | 1377 | Ring stretch | 1619 | Ring stretch |
| | N-acetyl-L-cysteine (NAC) [47, 55] | | 652 | ν(C-S) | 763 | δ(C-SH) | 818 | δ(HCS) | 950 | δ(NCH) + δ(HCH) | 1582 | Amide I |
| | D-penicillamine (DPA) [56] | | 638 | ν(C-S) | 819 | δip(C-H) | 1182 | δip(C-H) + ν(C-N) | 1267 | δ(C-H) | 1374 | ν(OCO) |
| | 4-Mercaptobenzoic acid (4-MBA) [57–59] | | 797 | δ(OCO) | 1074 | Ring stretch | 1179 | δ(C-H) | 1479 | ν(C-C) + ν(C-H) | 1588 | Ring stretch |
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Abbreviations: Rs, Raman shift; ν, stretching; δ, bending; ip, in plane.
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