Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS

Figure 2

Representative MRM chromatograms of six TKIs: (a) blank sample; (b) blank sample spiked with the LLOQ concentration of six TKIs and IS; (c) real sample concentration (icotinib: 504 ng/mL, erlotinib: ND, gefitinib: 623 ng/mL, crizotinib: 327 ng/mL, afatinib: ND, osimertinib: 250 ng/mL, and IS: 100 ng/mL). ND = not detected.

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