Research Article
Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS
Table 2
Linearity regression parameters of six analytes.
| Analytes | Regression type | Linear range | Weighing factor | Regression equations | R |
| Gefitinib | Linearity | 10.0–1000.0 | 1/χ2 | y = 0.0025 ∗ x − 0.0029 | 0.9915 | Icotinib | Linearity | 50.0–4000.0 | 1/χ2 | y = 0.0011 ∗ x − 0.0129 | 0.9981 | Erlotinib | Linearity | 50.0–4000.0 | 1/χ2 | y = 0.0024 ∗ x − 0.0275 | 0.9986 | Crizotinib | Linearity | 10.0–1000.0 | 1/χ2 | y = 0.0193 ∗ x − 0.4494 | 0.9940 | Osimertinib | Linearity | 10.0–1000.0 | 1/χ2 | y = 0.0016 ∗ x − 0.0023 | 0.9911 | Afatinib | Linearity | 5.0–400.0 | 1/χ2 | y = 0.0141 ∗ x − 0.4145 | 0.9934 |
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