Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS

Table 2

Linearity regression parameters of six analytes.

Analytes	Regression type	Linear range	Weighing factor	Regression equations	R
Gefitinib	Linearity	10.0–1000.0	1/χ^2	y = 0.0025 ∗ x − 0.0029	0.9915
Icotinib	Linearity	50.0–4000.0	1/χ^2	y = 0.0011 ∗ x − 0.0129	0.9981
Erlotinib	Linearity	50.0–4000.0	1/χ^2	y = 0.0024 ∗ x − 0.0275	0.9986
Crizotinib	Linearity	10.0–1000.0	1/χ^2	y = 0.0193 ∗ x − 0.4494	0.9940
Osimertinib	Linearity	10.0–1000.0	1/χ^2	y = 0.0016 ∗ x − 0.0023	0.9911
Afatinib	Linearity	5.0–400.0	1/χ^2	y = 0.0141 ∗ x − 0.4145	0.9934