Simultaneous and Rapid Determination of Six Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Using HPLC-MS/MS

Table 3

Precision and accuracy of the LLOQ of six analytes’ calibration curves.

Analytes	Nominal concentration (ng/mL)	Measured concentration (ng/ml) ± SD	Precision RSD (%)	Accuracy mean (%)
Gefitinib	10	8.82 ± 0.29	6.31	96.22
Icotinib	50	50.22 ± 0.91	1.81	100.44
Erlotinib	50	49.01 ± 0.92	1.87	98.01
Crizotinib	10	10.07 ± 0.36	7.27	101.39
Osimertinib	10	9.75 ± 0.21	4.31	95.15
Afatinib	5	5.30 ± 0.31	5.76	105.98