A Fast and Validated HPLC Method for the Simultaneous Analysis of Five 5-HT₃ Receptor Antagonists via the Quantitative Analysis of Multicomponents by a Single Marker

Table 7

The results obtained by the QAMS and ESM methods (n = 3).

Compound	The QAMS methods		The external standard methods
	Accuracy (%)	RSD (%)	Accuracy (%)	RSD (%)
The five 5-HT3receptor antagonists in injection dosage form
Azasetron	97.3	1.5	97.4	1.8
Granisetron	102.1	2.1	101.8	1.0
Tropisetron	101.7	0.9	102.1	1.6
Ondansetron	99.2	1.7	99.4	0.8
Ramosetron	101.3	2.4	100.9	1.4
The five 5-HT3receptor antagonists in infusion samples
Azasetron	94.9	1.3	95.1	1.5
Granisetron	100.3	0.8	99.8	0.7
Tropisetron	97.1	2.2	97.2	1.3
Ondansetron	103.6	1.9	103.8	1.2
Ramosetron	98.8	1.5	99.0	0.9