A Brief Review of Analytical Methods for the Estimation of Allopurinol in Pharmaceutical Formulation and Biological Matrices

Table 1

UV-visible and spectrofluorimetric methods for the determination of allopurinol.

S. no.	Drugs	Pharmaceutical matrix	Wavelength (nm)	Linearity (μg·mL^−1)	Assay (%)	Accuracy of the study (%)	Ref.
UV-visible spectrophotometric methods
1.	ALLP	Tablet	580	2–10	98.2–102.5	100	[16]
2.	ALLP and LA	Tablet	250 and 310–390	10–50	101.2 and 100.69	101.18–101.61 and 100.81–101.84	[17]
3.	ALLP	Tablet	450 and 515	10–70	101.1 and 101.4	98.40–100.7 and 98.20–100.4	[18]
4.	ALLP and UA	Urine	284 and 293	0.2–1.2 mg/100 ml	99.25 and 98,97	100.14 and 100.23	[19]
5.	ALLP and FC	Tablet	281 and 275	0.25–3.5	99.01–102.24 and 99.88–101.89	99.75 and 99.84	[20]
6.	ALLP and LSD	Tablet	252–228, 240, and 290	1–16 μg mL^–1 and 3–45 μg mL^–1	99.98–100.23 and 100.05	99.77–100.22 and 100.26	[21]
Spectrofluorimetry
7.	CM, TB, CB, and ALLP	Tablet	535/365	1–6 for CM and CB, 0.75–6 for TB, and 4–16 for ALLP	—	99.75–101.04	[23]
8.	LSD and ALLP	Tablet and human plasma	288/343; 465/535	0.25–4.0 μg mL^–1 for LSD and 0.2–20 μg mL^–1 for ALLP	100.41 and 99.28	99.55 and 100.18	[24]