Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Parameter</td><td class="align_center">Observed result</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Linearity range</td><td class="align_center">5–30 <i>μ</i>g/ml</td></tr><tr><td class="align_left">Calibration equation</td><td class="align_center"><i>Y</i> = 98881<i>x</i> + 71.42</td></tr><tr><td class="align_left">Slop</td><td class="align_center">98881</td></tr><tr><td class="align_left">Intercept</td><td class="align_center">71.42</td></tr><tr><td class="align_left">Limit of detection</td><td class="align_center">0.254 <i>μ</i>g/ml</td></tr><tr><td class="align_left">Limit of quantification</td><td class="align_center">0.838 <i>μ</i>g/ml</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

International Journal of Analytical Chemistry

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Table 4

Table 4: Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method 

Table 4 | Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method 