Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry

Table 1

Accuracy and precision of QC samples in human plasma and oral fluid.

Sample matrix drug		QC (ng/mL)	Intraday (n = 6)		Interday (n = 18)
			RSD (%)	Accuracy (%)	RSD (%)	Accuracy (%)
Plasma	(R)	75	5.7	−8.8	4.9	−5.7
		250	2.4	−5.9	2.2	−6.1
		500	5.1	−10.3	6.6	−2.4
	(S)	75	2.3	−3.5	4.4	−4.4
		250	5.0	−7.0	3.2	−1.9
		500	5.8	−7.1	5.6	−7.0
Oral fluid	(R)	75	5.3	−5.5	5.3	−3.5
		150	4.3	−3.7	4.5	8.3
		250	4.6	−4.0	3.5	−5.4
	(S)	75	5.6	5.0	7.5	4.8
		150	4.5	−4.7	5.3	−9.9
		250	4.2	6.9	5.0	−5.7