Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry

Table 4

Main pharmacokinetic parameters of OME enantiomers in plasma and oral fluid following single oral dose of 20 mg to healthy volunteers (n = 4).

Parameter	Plasma		Oral fluid
	(R)-OME	(S)-OME	(R)-OME	(S)-OME
Cmax (ng·mL^−1)	62.44	97.24	40.01	43.61
Tmax (h)	2.50	2.50	2.00	2.00
kel (h^−1)	0.267	0.207	1.811	1.151
t1/2 (h)	2.59	3.35	0.58	0.60
AUC0−24	384.86	510.80	125.99	130.66
AUC0−∞	411.72	544.25	128.59	134.79
CL/f (L·kg^−1·h^−1)	0.631	0.477	1.944	1.855
VD/f (L·kg^−1)	2.361	2.306	1.073	1.611