Determination of Gypenoside A and Gypenoside XLIX in Rat Plasma by UPLC-MS/MS and Applied to the Pharmacokinetics and Bioavailability

Table 1

Accuracy, precision, matrix effect, and recovery of gypenoside A and gypenoside XLIX in rat plasma.

Compound	Concentration (ng/mL)	Accuracy (%)		Precision (RSD%)		Matrix effect (%)	Recovery (%)
		Intraday	Interday	Intraday	Interday
Gypenoside A	2	90.1	107.5	13.8	14.9	89.9	92.7
	5	103.2	90.5	7.0	6.4	93.5	88.3
	250	100.0	102.9	8.5	7.9	93.9	95.0
	2500	101.8	103.3	6.1	9.9	87.1	89.4
	2	91.8	113.9	10.4	12.9	90.4	97.1
Gypenoside XLIX	5	108.9	94.2	8.1	10.4	92.9	94.4
	250	106.2	106.1	8.1	11.3	94.1	93.2
	2500	99.3	94.2	6.1	4.4	89.3	98.2