Research Article
An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers of Pheretima
Table 1
Optimization of the results of the orthogonal experimental design.
| No. | Ratio of sample to liquid (A, mg/mL) | Extraction time (B, min) | Extraction temperature (C, °C) | Extraction power (D, W) | Total content (mg/g) |
| 1 | 10 | 40 | 40 | 220 | 3.6466 | 2 | 10 | 50 | 50 | 290 | 3.6795 | 3 | 10 | 60 | 60 | 360 | 3.7052 | 4 | 20 | 40 | 50 | 360 | 3.1518 | 5 | 20 | 50 | 60 | 220 | 3.1720 | 6 | 20 | 60 | 40 | 290 | 3.1203 | 7 | 30 | 40 | 60 | 290 | 3.0463 | 8 | 30 | 50 | 40 | 360 | 2.8356 | 9 | 30 | 60 | 50 | 220 | 3.0658 | K1 | 3.677 | 3.282 | 3.201 | 3.295 | | K2 | 3.148 | 2.229 | 3.299 | 3.282 | | K3 | 2.983 | 3.297 | 3.308 | 3.231 | | R | 0.694 | 0.068 | 0.107 | 0.064 | |
| Order | A > C > B > D | Optimal level | 10 | 60 | 60 | 220 | | Optimal combination | 10 mg/mL, 60 min, 60°C, 220 W |
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Note: Ki: the average of each level in each factor; R: the difference between the maximum and minimum levels of each factor.
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