Research Article
Determination of Tenacissoside G, Tenacissoside H, and Tenacissoside I in Rat Plasma by UPLC-MS/MS and Their Pharmacokinetics
Table 1
Accuracy, precision, matrix effect, and recovery of tenacissoside G, tenacissoside H, and tenacissoside I in rat plasma.
| | Compound | Concentration (ng/mL) | Accuracy (%) | Precision (RSD%) | Matrix effect (%) | Recovery (%) | | Intraday | Interday | Intraday | Interday |
| | Tenacissoside G | 5 | 90.6 | 110.5 | 10.0 | 10.0 | 108.5 | 92.9 | | 8 | 108.8 | 99.0 | 8.4 | 4.8 | 94.5 | 92.2 | | 180 | 99.4 | 105.5 | 5.3 | 9.3 | 102.3 | 97.3 | | 1800 | 104.4 | 104.9 | 8.1 | 4.8 | 99.8 | 94.4 |
| | Tenacissoside H | 5 | 91.1 | 97.9 | 13.0 | 11.8 | 106.9 | 97.2 | | 8 | 88.2 | 109.8 | 10.2 | 9.1 | 101.8 | 96.9 | | 180 | 100.9 | 92.8 | 11.0 | 8.3 | 102.1 | 90.6 | | 1800 | 96.2 | 114.5 | 6.8 | 2.0 | 107.8 | 88.6 |
| | Tenacissoside I | 5 | 95.3 | 88.8 | 8.8 | 14.1 | 92.8 | 83.5 | | 8 | 93.2 | 105.8 | 7.2 | 6.4 | 91.3 | 83.0 | | 180 | 109.8 | 101.6 | 10.0 | 10.7 | 94.1 | 80.6 | | 1800 | 101.3 | 92.9 | 9.0 | 7.8 | 98.5 | 85.8 |
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