Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons

Table 3

Hazard ratios and 95% CIs for all-cause mortality according to %dSUA quintiles by subanalysis.

Baseline characteristics	N	%dSUA quintiles			for trend
		Hazard ratio (95% CI)
		Quintile 1	Quintiles 2–4	Quintile 5
		<−1.88% (year)	−1.87 to 2.50% (year)	≥2.51% (year)
Age
<65 years	646	5.82 (2.07–16.4)	1.00	0.75 (0.17–3.38)	0.003
≥65 years	655	2.77 (1.21–6.37)	1.00	0.98 (0.43–2.22)	0.043
Body mass index
<22.0 kg/m^2	496	7.59 (2.13–27.0)	1.00	2.93 (1.05–8.18)	0.005
≥22.0 kg/m^2	805	3.08 (1.46–6.48)	1.00	0.42 (0.13–1.42)	0.002
Medication^#
Absence	818	4.32 (1.98–9.44)	1.00	0.33 (0.08–1.39)	≤0.001
Presence	483	2.85 (1.03–7.90)	1.00	1.59 (0.62–4.04)	0.334
Chronic kidney disease
eGFR <60 mL/min/1.73 m^2	95	1.80 (0.22–14.8)	1.00	20.0 (1.09–369)	0.112
eGFR ≥60 mL/min/1.73 m^2	1,206	4.07 (2.06–8.06)	1.00	0.73 (0.32–1.66)	<0.001
Hyperuricemia
SUA <6.0 for men or <5.0 for women	806	4.67 (1.94–11.2)	1.00	0.91 (0.41–2.03)	≤0.001
SUA ≥6.0 for men or ≥5.0 for women	495	3.39 (1.26–9.16)	1.00	3.08 (0.62–15.2)	0.042

%dSUA, percentage change in serum uric acid; CI, confidence interval. ^#Antihypertensive medication, antidyslipidemic medication, antidiabetic medication. Multivariable-adjusted for gender, age, body mass index, smoking habits, drinking habits, history of cardiovascular disease, hypertension, hypertriglyceridemia, low HDL-cholesterolemia, hyper LDL-cholesterolemia, diabetes, chronic kidney disease, and hyperuricemia. Bolded numbers indicate significance ().