Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

Table 2

In vivo biodistribution of ¹²⁵I-CQ-BCA-NPs by IV administration in wild type mice (𝑛=105) (NP polymerized in the presence of 1% Dextran 70 000 and 1% Tween-80; the table represents organ uptakes in %ID/g ± SD).

Time (min)	Brain	Blood	Spleen	Liver	Brain:bloodratio
2	2.3±0.9	12±2.5	1.6±0.4	15±2.1	0.2±0.1
5	1.5±0.9	7.9±1.6	1.8±0.5	11.4±1.5	0.2±0.1
15	0.5±0.2	4.9±1.2	1.4±0.5	8.1±2.1	0.1±0.1
30	0.3±0.1	3.4±1.5	0.9±0.7	6.6±2.4	0.1±0.0
60	0.2±0.1	2.1±1.1	0.5±0.3	3.9±1.6	0.1±0.0
120	0.03±0.0	0.7±0.2	0.2±0.03	2.3±0.4	0.1±0.0
240	0.02±0.0	0.4±0.0	0.1±0.1	1.4±0.1	0.01±0.0

𝑃=.05