Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Table 2

Odds ratios (ORs) for risk of dementia associated with log-transformed levels of total homocysteine (tHcy).

		Number	Crude		Number	Model 1^a		Number	Model 2^b
Group	Risk factor	Cases/Total	OR	95% CI	Cases/Total	OR	95% CI	Cases/Total	OR	95% CI
Total sample	log(tHcy)	169/2100	6.3^∗∗	4.2–9.3	152/1787	4.2^∗∗	2.4–7.3	152/1786	3.6^∗∗	2.0–6.4
55–66 years	log(tHcy)	23/1094	4.6^∗	1.7–12.3	21/927	6.3^∗	1.6–24.6	21/927	4.5	0.9–20.5
>66 years	log(tHcy)	146/1006	4.7^∗∗	2.9–7.5	131/860	4.2^∗∗	2.3–7.8	131/859	3.8^∗∗	2.0–7.2

aModel 1 adjusted for age, sex, education, diabetes, APOE genotype, folate, and vitamin B12; bModel 2 adjusted for age, sex, education, diabetes, APOE genotype, folate, vitamin B12, and stroke, ^∗𝑃≤.02; ^∗∗𝑃<.001.