Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Table 3

Comparison of risk associated with total homocysteine (tHcy) for Alzheimer’s disease (AD) and vascular dementia (VaD).

		No.	Crude		No.	Adjusted^a
Group	Risk factor	Cases/Total	OR	95% CI	Cases/Total	OR	95% CI
AD	log(tHcy)	74/2005	4.3^∗	2.5–7.5	65/1701	1.9	0.9–4.2
VaD	log(tHcy)	48/1979	7.8^∗	4.1–15.1	45/1681	4.6^∗	2.0–11.1

aAdjusted model includes age, sex, education, diabetes, folate, vitamin B12, and APOE genotype; ^∗𝑃≤.001, criteria from the NINCDS/ADRDA [34] were used to diagnose AD and criteria from the ADDTC [35] to diagnose VaD.