Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

Figure 3

Ultrastructural localization of anti-A𝛽 N-terminal immunoreactions (𝛼A𝛽 N-terminal IRs) in aged NEP^−/−APP⁺ (a) and aged NEP^+/+APP⁺ (b) mouse brain sections. (a) 𝛼A𝛽 N-terminal IRs (arrow, representative) were strongly observed on amyloid fibrils in senile plaques. Ax: axon, Den: dendrite, and AT: axon terminal. (b) Intracellular 𝛼A𝛽 N-terminal IRs observed on Golgi apparatus (Go) and lysosomes (Ly) in neuron. Scale bar = 200 nm. Nu: nucleus, Mit: mitochondria.

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