Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

Figure 4

Density of 𝛼APF-IRs at the cell processes in mouse brain tissue. In the young group, the density was significantly higher in NEP^−/−APP⁺ mice than that in NEP^+/+APP⁻ mice (^**, 𝑃<.01, Scheffe’s multiple test). In the aged group, the densities were significantly higher in NEP^−/−APP⁺ and NEP^+/+APP⁺ mice than that in NEP^+/+APP⁻ mice (^**, 𝑃<.01, Scheffe’s multiple test).