Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

Table 1

Distribution of anti-annular protofibril immunoreactions (𝛼APF-IRs) localized to cell processes.

Process		Axon	Axon	Dendrite	Postsynaptic	Unidentified	Total(a)
Type			Terminal		Process
Young	NEP^+/+APP^−	0(0.0%)(b)	0 (0.0)	1 (33.3)	0 (0.0)	2 (66.7)	3
	NEP^+/+APP^+	3 (18.8)	0 (0.0)	1 (6.3)	1 (6.3)	11 (68.8)	16
	NEP^−/−APP^+	3 (12.5)	0 (0.0)	1 (4.2)	2 (8.3)	18 (75.0)	24
Aged	NEP^+/+APP^−	3 (23.1)	1 (7.7)	0 (0.0)	0 (0.0)	9 (69.2)	13
	NEP^+/+APP^+	11 (18.3)	6 (10.0)	1 (1.7)	0 (0.0)	42 (70.0)	60
	NEP^−/−APP^+	16 (17.6)	12 (13.2)	2 (2.2)	5 (5.5)	56 (61.5)	91

(a)The number of photo prints examined was 150 for each age and genotypic group. (b)The number and percentage of total𝛼APF-IRs.