Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

Table 2

The number and percentage of 𝜶APF-positive and -negative synapses.

		Positive	Negative	Total(𝐚)
Young	NEP^+/+APP^−	0 (0.0%)(b)	255 (100.0)	255
	NEP^+/+APP^+	1 (0.3)	300 (99.7)	301
	NEP^−/−APP^+	2 (0.7)	302 (99.3)	304
Aged(c)	NEP^+/+APP^−	1 (0.4)	261 (99.6)	262
	NEP^+/+APP^+	6 (2.1)	283 (97.9)	289
	NEP^−/−APP^+	17 (5.4)	297 (94.6)	314

(a)The total number of synapses observed in 150 photo prints for each group. (b)The number and percentage of total synapses. (c)The positive rate was significantly higher in aged Alzheimer model Tg mice than in aged non-transgenic mice. 𝑃<.01, 𝜒² for independence test.