International Journal of Alzheimer’s Disease / 2009 / Article / Tab 2

Research Article

Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Table 2

Effect of Centella asiatica (CA; 150 and 300 mg/kg, PO) on memory performance in elevated plus maze paradigm in intracerebroventricular colchicines- (COL-) injected rats.

Treatment (mg/kg)Mean transfer latency (in seconds)
ITL1st RTL2nd RTL

Sham
ACSF
COL
CA (150)
CA (300)
CA (150) + COL
CA (300) + COL

The initial transfer latencies (ITLs) on day 13 and retention transfer latencies on days 14 (1st RTL) and 21 (2nd RTL) following colchicine injection were observed. Values are mean SEM; as compared to artificial cerebrospinal fluid (ACSF)-injected group; as compared to colchicine-injected group; as compared to CA (150) COL group; (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons). Note: ACSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella. asiatica