Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Table 3

Effect of Centella asiatica (CA; 150 and 300 mg/kg, PO) on spatial navigation task in intracerebroventricular colchicines- (COL-) injected rats.

Treatment (mg/kg)	Mean latency (in seconds)
	IAL	1st RL	2nd RL
Sham	43.5±1.29	12.33±1.4	9.16±2.16
ACSF	55.33±1.7	14.33±1.66	11.8±1.49
COL	88.0±1.93^a	75.0±1.43^a	62.33±1.80^a
CA (150)	62.33±1.51	12.83±1.945	10.16±2.16
CA (300)	60.8±1.077	11.83±1.09	9.66±1.421
CA (150) + COL	70.6±2.470^b	40.0±1.577^b	32.15±0.475^b
CA (300) + COL	66.66±1.438^b,c	26.0±0.569^b,c	21.5±1.576^b,c

The initial acquisition latencies (IALs) on day 13 and retention latencies on days 14 (1st RL) and 21 (2nd RL) following colchicine injection were observed in Morris water maze. Values are mean ± SEM; ^a𝑃<.05 as compared to artificial cerebrospinal fluid- (ACSF) injected group; ^b𝑃<.05 as compared to colchicine-injected group; ^c𝑃<.05 as compared to CA (150) + COL group; (Repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons). Note: ACSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella asiatica.