Table 4: Effect of Centella asiatica (CA; 150 and 300 mg/kg, PO) on colchicines-induced oxidative stress parameters in rat brain.

Treatment (mg/kg) MDA levels nmol MDA/mg protein (% of sham) Nitrite levels mol/mg protein (% of sham) Reduced glutathione nmol/mg protein (% of sham) Catalase  mol of hydrogen peroxide decomposed/min/mg protein ( % of sham) Superoxide dismutase Units/mg protein (% of sham) Glutathione- S- transferase nmol of CDNB conjugated/min/mg protein (% of sham) Sham 100 10 100 12 100 10 100 12 100 14 100 12 ACSF 114.28 11 109.33 11 103.33 11 97.05 10 97.52 15 98.66 16 COL 339.88 3 298.39 1 23.38 1 17.98 13.47 18.67 CA (150) 106.7 15 101.29 16 90.35 17 93.9 13.7 99.17 17 97.64 14 CA (300) 123.4 28 99.44 26 93.77 15 98.8 10.8 98.16 16 98.65 13 CA (150) COL 229.81 2 210.91 50.45 36.96 39.05 1 30.65 CA (300) COL 157.26 1 148.98 7. 81.61 7. 69.71 65.52 65.05

Values are mean SEM; as compared to artificial cerebrospinal fluid- (ACSF-) injected group; as compared to colchicine-injected group; as compared to CA (150) COL group; (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons). Note: ACSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella asiatica.