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International Journal of Alzheimer’s Disease

International Journal of Alzheimer’s Disease / 2009 / Article / Tab 4

Research Article

Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Table 4

Effect of Centella asiatica (CA; 150 and 300 mg/kg, PO) on colchicines-induced oxidative stress parameters in rat brain.
Treatment (mg/kg)MDA levels nmol MDA/mg protein (% of sham)Nitrite levels mol/mg protein (% of sham)Reduced glutathione nmol/mg protein (% of sham)Catalase   mol of hydrogen peroxide decomposed/min/mg protein ( % of sham)Superoxide dismutase Units/mg protein (% of sham)Glutathione- S- transferase nmol of CDNB conjugated/min/mg protein (% of sham)
Sham100 10100 12100 10100 12100 14100 12
ACSF114.28 11109.33 11103.33 1197.05 1097.52 1598.66 16
COL339.88 3 298.39 1 23.38 1 17.98 13.47 18.67
CA (150)106.7 15101.29 1690.35 1793.9 13.799.17 1797.64 14
CA (300)123.4 2899.44 2693.77 1598.8 10.898.16 1698.65 13
CA (150) COL229.81 2 210.91 50.45 36.96 39.05 1 30.65
CA (300) COL157.26 1 148.98 7. 81.61 7. 69.71 65.52 65.05
Values are mean SEM; as compared to artificial cerebrospinal fluid- (ACSF-) injected group; as compared to colchicine-injected group; as compared to CA (150) COL group; (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons). Note: ACSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella asiatica.