Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Figure 2

Peripheral physiological-immunoendocrine function is differentially impaired in male and female 3xTg-AD mice and is not ameliorated by treadmill exercise. (a) The IPGT test, indicating plasma glucose levels after an ip injection of glucose, denoted lower tolerance in female 3xTg-AD (see text for statistics). (b–d) Immunoendocrine function as measured by corticosterone plasma levels (b), white adipose tissue (WAT) weight (c), and thymus weight (d) was better in females than in males. Values are the mean ± SEM, 𝑛=8-10. Statistics: ^∗𝑃<.05 and ^∗∗∗𝑃<.001 compared to the corresponding non-Tg;^#𝑃<.05, ^##𝑃<.01, and ^###𝑃<.001 compared to the corresponding TgSED.

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