Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
Oxidative stress in the cerebral cortex of sedentary male 3xTg-AD mice (TgSED) is partially ameliorated by treadmill running exercise (TgEXE), whereas 3xTg-AD females show less alteration. Tissue of sedentary nontransgenic mice (non-Tg) was analyzed as a reference. (a) Lipid peroxidation levels expressed as malondialdehyde (MDA) plus 4-hydroxyalkenal (4-HAD). (b) Levels of reduced glutathione (GSH). (c) Levels of oxidized glutathione (GSSG). (d) Glutathione peroxidase (GPx) enzymatic activity. (e) SOD-CuZn enzymatic activity. (f) SOD-Mn activity. Data represent the mean ± SEM of 4–8 animals, tested in duplicate. Statistics: , , and compared to non-Tg; compared to TgSED.
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