Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Table 2

Treadmill exercise recovers the [³H] flunitrazepam binding parameters of cerebral cortical tissue of 3xTgAD mice.

		non-Tg	TgSED	TgEXE
Males	Bmax (pmol/mg prot)	1.77 ± 0.32	1.85 ± 0.36	1.58 ± 0.43
	Kd (nM)	3.85 ± 0.73	6.46 ± 0.69*	3.64 ± 0.69^#
Females	Bmax (pmol/mg prot)	1.21 ± 0.43	1.45 ± 0.65	1.27 ± 0.30
	Kd (nM)	3.46 ± 1.61	4.03 ± 2.80	3.20 ± 1.08

Note: non-Tg, nontransgenic mice; TgSED, 3xTgAD mice not exercised; TgEXE, 3xTg-AD mice submitted to a daily treadmill running for five weeks. Exercise protected against the decrease of the affinity of [³H] flunitrazepam for its binding site in the GABA-A receptor, as showed by a low Kd. Results are the mean ± SEM, 𝑛=3. Statistics: ^∗𝑃<.05 compared to non-Tg; ^#𝑃<.01 compared to TgSED.