Gene symbol Name Interaction with HSV-1 proteins AATF Apoptosis antagonizing transcription factor — ABL1 V-abl Abelson murine leukemia viral oncogene homolog 1 — ACTB Actin, beta Virion component APOE Apolipoprotein E Binds to glycoprotein B BAG1 BCL2-associated athanogene — CALM1 Calmodulin 1 (phosphorylase kinase, delta) Phosphorylated by ICP10 CAMK2A Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha — CASP1 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) — CASP3 Caspase 3, apoptosis-related cysteine peptidase US3 phosphorylates procaspase 3 CASP6 Caspase 6, apoptosis-related cysteine peptidase — CASP7 Caspase 7, apoptosis-related cysteine peptidase Activated during HSV-1 mediated apoptosis CASP8 Caspase 8, apoptosis-related cysteine peptidase Activity inhibited by LAT latency transcript CDK1 Cyclin-dependent kinase 1 — CDK5 Cyclin-dependent kinase 5 — FLJ10357 Hypothetical protein FLJ10357 — FYN FYN oncogene related to SRC, FGR, YES — GSK3A Glycogen synthase kinase 3 alpha — GSK3B Glycogen synthase kinase 3 beta Activated by HSV-1 infection HSPA8 Heat shock 70 kDa protein 8 Recruited to nuclear domains following infection: ICP0 dependent MAPK12 Mitogen-activated protein kinase 12 — MAPT Microtubule-associated protein tau Phosphorylated by viral infection via GSK3B and PRKACA MARK1 MAP/microtubule affinity-regulating kinase 1 — MARK4 MAP/microtubule affinity-regulating kinase 4 — OGT O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) — PARK2 Parkinson disease (autosomal recessive, juvenile) 2, parkin — PHKG1 Phosphorylase kinase, gamma 1 (muscle) — PIN1 Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 — PKN1 Protein kinase N1 — PPP2CA Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform — PPP2CB Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform — PPP2R5A Protein phosphatase 2, regulatory subunit B
, alpha isoform — PPP5C Protein phosphatase 5, catalytic subunit — PRKCD Protein kinase C, delta — PSEN1 Presenilin 1 (Alzheimer disease 3) — RPS6KA3 Ribosomal protein S6 kinase, 90 kDa, polypeptide 3 — RPS6KB1 Ribosomal protein S6 kinase, 70 kDa, polypeptide 1 — S100B S100 calcium binding protein B — SNCA Synuclein, alpha (non-A4 component of amyloid precursor) — SPTB Spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) — STAU1 Staufen, RNA binding protein, homolog 1 (Drosophila) — STUB1 STIP1 homology and U-box containing protein 1 — STXBP1 Syntaxin binding protein 1 — TUBA4A Tubulin, alpha 4a — TUBB Tubulin, beta — UBC Ubiquitin C Virion component YWHAB Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide — YWHAZ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Virion component
