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International Journal of Alzheimer’s Disease
Volume 2010 (2010), Article ID 163065, 4 pages
Review Article

Cerebrospinal Fluid Analysis Should Be Considered in Patients with Cognitive Problems

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 431 80 Mölndal, Sweden

Received 16 January 2010; Accepted 2 March 2010

Academic Editor: Lucilla Parnetti

Copyright © 2010 Henrik Zetterberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatologists assay liver enzymes and cardiologists structural heart proteins in serum to diagnose and monitor their patients. This way of thinking has not quite made it into the memory clinics yet, in spite of the availability of validated cerebrospinal fluid biomarkers for key pathological events in the brain in neurodegeneration. Here, we argue that a spinal tap should be considered in all patients who seek medical advice for memory problems and list the highly relevant clinical questions CSF analyses can address.