Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?

Figure 1

Photomicrographs illustrating the two cases' similarity of amyloid A𝛽42 plaques and marked difference in AD-like pathology. Panel (a) shows tau pathology with NFT and neuropil threads of case 1 which are absent in case 2 (panel (b)). Panels (c) and (d) show equally high A𝛽42 plaque densities of cases 1 (c) and 2 (d). Location: prefrontal cortex (middle frontal gyrus); immunohistochemistry: tau-5 ((a) and (b)) and 21F12 ((c) and (d)); magnification: 400 X ((a) and (b)) and 100 X ((c) and (d)).

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