The Chick as a Model for the Study of the Cellular Mechanisms and Potential Therapies for Alzheimer's Disease

Table 2

Effect of anti-APP and APP antisense on memory retention.

	Time of injection	Memory retention (%  Avoidance)	Time of injection	Memory retention (%  Avoidance)
Control (Saline, non-immune sera)	30 minutes pre-training	78–95	5.5 hours Posttraining	78–95
Anti APP	30 minutes pre training	28–35^∗∗	5.5 hours Posttraining	78–95
Control (SC)	6 hours pre-training	78–95	30 minutes pre-training	78–95
AS	6 hours pre-training	32–37^∗	30 minutes pre-training	7 8–95

𝑁=18-25; ^∗𝑃<.05; ^∗∗𝑃<.01.
Anti APP: monoclonal human antibody mAb22C11 [17]; AS: 16-mer end-protected phosphodiester oligodeoxynucleotide, 5^′ CXC GAG GAC TGA XCC A 3^′, designed to correspond to the transcription start sites −146 and AUG1786 of the 𝛽APP mRNA, immediately upstream of a ribozyme binding site [17]; SC: Scrambled AS sequence [17]; For further details see [18, 49, 50].