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International Journal of Alzheimer’s Disease
Volume 2010, Article ID 393579, 9 pages
Review Article

Prevention of Dementia: Focus on Lifestyle

1Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, 44627 Herne, Germany
2Department of Neurology, St. Elisabeth-Krankenhaus Köln, 50935 Cologne, Germany

Received 8 February 2010; Accepted 10 May 2010

Academic Editor: Vincenzo Solfrizzi

Copyright © 2010 Maria Cristina Polidori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this paper is to summarize current knowledge on the possible advantages of lifestyle interventions, with particular attention to physical fitness, cognitive activity, leisure and social activity as well as nutrition. There is a large amount of published papers providing partial evidence and asserting the need for immediate, appropriate preventive lifestyle measures against dementia and AD development. Nevertheless, there are currently great difficulties in drafting effective guidelines in this field. This depends mainly upon lack of randomized controlled trials assessing benefits versus risks of particular lifestyle interventions strategies. However, due to the rapid increase of dementia burden, lifestyle factors and their amelioration should be already made part of decision making in light of their health-maintaining effects while awaiting for results of well-designed large prospective cohort studies in dementia.