Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease

Figure 2

Proposed mechanism of Aβ peptide and N-ter Tau fragment interaction with mitochondria; for further details see text. mom, mitochondrial outer membrane; mim, mitochondrial inner membrane; TOM, translocase of the outer membrane; I–V, respiratory chain complexes; cyt c, cytochrome c; ANT, adenine nucleotide translocator; CyD, cyclophilin D; mPTP, mitochondrial permeability transition pore.