Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease

Figure 4

Schematic overview of the interplay between Aβ, Tau, oxidative/nitrosative stress, and mitochondria; see text for details. GC, guanylil cyclase; cGMP, cyclic GMP; NOS, nitric oxide synthase; 𝑂₂^•−, superoxide anion; 𝑂𝑁𝑂𝑂⁻, peroxynitrite; ANT, adenine nucleotide translocator; GSK3beta, glycogen synthase kinase-3beta; GEN, Genistein.