Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

Figure 3

AβP1-40 channel mean conductance and frequency in OxCh PLM in the absence and in the presence of choline. (a) Λ_𝑐±SE and (b) frequency ± SD of AβP1-40 channel without and with choline (5 × 10⁻¹¹ M) added to the cis or trans side of the chamber in OxCh PLM. The minimum and maximum number of channels considered (N) out of a total number of channels considered (𝑁_𝑡) was: AβP1-40, 448<𝑁<2080, 𝑁_𝑡=5493; AβP1-40 + choline cis, 115<𝑁<898, 𝑁_𝑡=2269; AβP1-40 + choline trans, 448<𝑁<948, 𝑁_𝑡=3844.

(a)

(b)