Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

Figure 5

AβP1-40 channel activity in POPC:Ch PLM. Representative AβP1-40 channel in the absence (a) or in the presence of choline (5 ×10⁻¹¹M) on the cis (b) or on the trans (c) side of the medium facing a POPC:Ch (65 : 35, w/w) PLM at an applied voltage of 60 mV. Amplitude histograms of channel conductance for each trace are shown next to their respective traces.

(a)

(b)

(c)