Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane
Figure 7
AβP1-40 channel ion selectivity in OxCh PLM. AβP1-40 channel selectivity in the presence of choline (5 × 10−11 M) cis (a) or trans (b) in OxCh PLM. The amplitude of the channel current (pA) is plotted as a function of the transmembrane potential (). Conductance was determined by linear regression of the current values from −30/−20 mV to 40/20 mV (choline cis/trans) in asymmetrical solutions 100 mM/50 mM KCl cis/trans. Intercept (5.76/7.76 mV, choline cis/trans) was used to calculate /.
