Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane
Figure 8
AβP1-40 channel ion selectivity in POPC:Ch PLM. AβP1-40 channel selectivity (a), in the presence of choline (5 ×10−11 M) cis (b) or trans (c) side in POPC:Ch (65 : 35, w/w) PLM. The amplitude of the channel current (pA) is plotted as a function of the transmembrane potential (). Conductance was determined by linear regression of the current values from −150 to 100 mV (a) and from −40/−80 mV to 40/40 mV (choline cis/trans) in asymmetrical 100 mM/50 mM KCl cis/trans solutions. Intercept (9.76/5.76/7.76 mV, (a)/(b)/(c) resp.) was used to calculate /.
