Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

Table 2

The channel lifetime of AβP1-40 in POPC:Ch PLM. The fitted lifetime (see text) of AβP1-40 (a), AβP1-40 and choline (5 ×10⁻¹¹ M) added to the cis/trans side of the chamber (b/c, resp.) channels in the POPC:Ch membrane. The minimum and maximum number of channels considered (N) out of a total number of channels considered (𝑁_𝑡) was: (a) 94<𝑁<240, 𝑁_𝑡=448; (b) 120<𝑁<196, 𝑁_𝑡=435; (c) 19<𝑁<111, 𝑁_𝑡=205. F-test, ^∗𝑃≥.078; ^∗∗𝑃=.39; ^∗∗∗𝑃=0.37.

Vs (mV)	a	b	c
	𝜏1^∗ (s)	𝜏1 (s)	𝜏1 (s)
100	2.50	1.72^∗∗	—
80	3.13	3.03	2.99^∗∗∗
60	3.25	2.32	3.11