Combined Analysis of CSF Tau, A𝛽42, A𝛽1–42% and A𝛽1–40^ox% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia

Table 2

Cutoff points, sensitivities, and specificities.

differential diagnosis	Parameter	cut off	sensitivity	specificity	Youden index	AUC	95%-CI
AD versus DLB	A𝛽42/tau	1.163	80%	53%	0.33	0.664	0.483–0.845
	A𝛽1–42%	5.093	80%	100%	0.80	0.933	0.872–0.994
	A𝛽1–40^ox%	1.144	89%	87%	0.76	0.908	0.802–1.014
AD versus PDD	A𝛽42/tau	1.450	91%	67%	0.58	0.775	0.630–0.919
	A𝛽1–42%	5.730	93%	86%	0.79	0.889	0.773–1.005
	A𝛽1–40^ox%	1.104	87%	43%	0.30	0.592	0.420–0.763
AD versus DLB and PDD	A𝛽42/tau	1.450	91%	56%	0.47	0.728	0.610–0.747
	A𝛽1–42%	5.093	80%	92%	0.72	0.907	0.834–0.981
	A𝛽1–40^ox%	1.104	87%	61%	0.48	0.723	0.600–0.847
DLB versus PDD	A𝛽42/tau	3.229	93%	43%	0.36	0.663	0.487–0.840
	A𝛽1–42%	8.855	80%	33%	0.13	0.597	0.395–0.799
	A𝛽1–40^ox%	1.244	80%	71%	0.51	0.810	0.667–0.952
DLB versus AD and PDD	A𝛽42/tau	0.546	80%	26%	0.06	0.560	0.396–0.723
	A𝛽1–42%	5.198	87%	61%	0.59	0.765	0.658–0.871
	A𝛽1–40^ox%	1.144	87%	80%	0.67	0.877	0.769–0.985