Figure 7: Schematic drawings showing the distribution of AT8-ir neurons in transcardially fixed 3-week, 3-, and 6-month-old 3xTg-AD mice. At 3 weeks, only scattered AT8-ir neurons were found in the cortex and basolateral amygdala compared to a greater number in the ventral hippocampus. Note that with increasing age, many more AT8-ir were found in the cortex, hippocampus, and amygdala. Abbreviations are the same as in Figure 2. Small dots = 1–5 positive neurons, medium-size dots = 10–20 positive neurons, and large dots = 100 positive neurons.