Effects of Immunomodulatory Substances on Phagocytosis of A by Human Microglia
Figure 9
Effects of interleukin-1β (IL-1β) and interferon-γ (IFNγ) on cell viability in human CHME3 microglial cells treated with Aβ 1–42 (grey boxes) or vehicle (white boxes). The cells were preincubated with 50 ng/mL IL-1β and 50 ng/mL IFNγ for 24 hours prior to addition of Aβ 1–42 (1 g/mL). At 24, 48, 72, and 96 hours after addition of Aβ 1–42 the viability of the cultures was assessed with the MTT assay. The data are expressed as % of control (vehicle) set at 100% and shown as median percentiles (25%–75% and 10%–90%), (24, 48 h), (72, 96 h). Statistical difference from vehicle is indicated by and , and statistical difference from Aβ 1–42 is indicated by and . indicates statistical difference between IFNγ and IL-1β IFNγ, and indicate differences between IL-1β and IL-1β IFNγ.
indicates statistical difference between IFNγ and IL-1β IFNγ, and indicate differences between IL-1β and IL-1β IFNγ.
