Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice
Figure 1
Effects of treatment with DSP4 on monoamine neurotransmitter levels. DSP4 (50 mg/kg in PBS, ) or PBS (vehicle, ) was administered intraperitoneally to C57BL/6SJL mice on days 1 and 7. Mice were sacrificed 7 days following the second injection (day 14). Brain was harvested and frontal cortex dissected for analysis of monoamine concentrations, demonstrating a 68% reduction of NE levels but no effect on serotonin.
