Table 1: The 10 most statistically significant metabolic differences in brain tissue, associated with transgenesis for Tg2576 that were observed after ablation of the locus coeruleus with DSP4 but not in animals in which the locus coeruleus had been left intact. The -value describes the false positive rate, the -value the false discovery rate.

CompoundLocus coeruleus ablated: Tg/wtLocus coeruleus intact: Tg/wtTg-ablated/wt-ablated (Ratio of means)Tg-intact/wt-intact (Ratio of means)

Glutathione, oxidized.0000.006.5360.6970.410.80
Glucose-6-phosphate.0010.051.1210.4580.780.88
D-arabitol.0010.051.1930.5050.691.12
Cholesterol.0020.051.8530.7521.510.95
Lactate.0020.051.1350.4610.841.06
Ascorbic acid.0030.051.2510.5300.730.92
Glutathione, reduced.0050.078.8290.7520.681.03
-glutamyl-leucine.0060.081.9680.7771.230.99
Octadecanoic acid.0090.101.0580.4231.121.07
Uric acid.0100.101.5760.7152.910.63