Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays
Figure 1
Workflow of bioinformatics analysis of promoter sequences and gene expression data to identify modules of TFBSs in AD-related genes. The workflow is divided into two parts, the first and second approach. The coloured boxes describe the methods which were used. The yellow boxes represent tools of the Genomatix Software (1DiAlignTF, 2FrameWorker, 3ModelInspector), and the blue boxes indicate multivariate methods or filtering by illumina detection score. The beginning and the end of the arrow specify input and output of the methods, respectively. The grey arrow denotes the comparison of the target genes of the modules with genes differentially regulated in microarray analyses. The scheme at the end of the second approach indicates a module composed of three TFBSs (blue, red, and green), which is common to three promoter sequences with transcription start site at the red arrow.
