Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays

Figure 2

Relations of predicted target genes of three TFBSs modules. This picture summarizes important target genes of the modules, the relation of target genes to KEGG pathways playing a role in AD (blue rectangle), and the relation of the target genes to some AD key genes (red pentagon). The target genes are coloured according to their membership to microarray studies, and some target genes with two colours are derived from analysis of two different microarray studies. The grey arrows are the predicted regulations of the target genes by the modules (orange rectangle), and the black lines indicate that the target gene is part of the corresponding KEGG pathway. Additionally, three different relations of the target genes to AD key genes are shown by purple, green, and blue lines, which indicate protein-protein binding, protein modification, and regulation, respectively.