Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays
Figure 3
Expression profiles of five different clusters of coregulated genes. On the -axis, the sample IDs (specified by accession numbers of GEO/NCBI) incorporated in the cluster are given, and -axis indicates values of expression. One gene corresponds to a single line in the profile, and the target genes of the modules as mentioned in the text are coloured. The two upper profiles (a, b) are clusters of coregulated genes of the AD patients dataset, the profile in the middle (c) corresponds to coregulated genes of the LOAD patients dataset, and the two profiles below (d, e) correspond to coregulated genes of the double-transgenic mice dataset. The target genes of the profiles (a) and (d) were used for the establishment of the module CTCF-EGRF-SP1F and the profiles (b) and (e) for the module CTCF-SP1F-ZBPF, at which (b) was also used for the module KLFS-SP1F-ZBPF. The five lines in profile (e) correspond to genes, which are involved in the MAPK signaling pathway. The target genes of the profile (c) were used for the establishment of the modules CTCF-SP1F-ZBPF and KLFS-SP1F-ZBPF.
