Research Article

Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays

Table 1

Modules identified by the first approach: 17 modules composed of two or more TFBSs families. The TFBSs families consist of several TFs (Table 2). The second column specifies the key genes of AD the TFs of the module bind to, according to the search of the module in all human promoters by ModelInspector. Human and mouse APPs are indicated by hAPP and mApp, respectively.

ModuleAD key genes—targets of module

CTCF-E2FF-SP1FhAPP, mApp, BACE1, NCSTN, APH1A,
CTCF-SP1FhAPP, mApp, BACE1, PS2, NCSTN, APH1A
E2FF-E2FF-EGRFhAPP, mApp, BACE1, BACE2, PEN-2, APH1A
CTCF-E2FF-EGRFhAPP, BACE2, PEN-2, NCSTN, APH1A
CTCF-E2FF-EGRFhAPP, mApp, BACE1, BACE2, PEN-2, APH1A
CTCF-HAND-SP1FhAPP, mApp, BACE2, PS2
CTCF-SP1F-SP1FhAPP, mApp, BACE1, BACE2
CTCF-NRF1-SP1FhAPP, mApp, BACE1, APH1A
CTCF-EGRF-NRF1hAPP, BACE2, PS2, PEN-2
CTCF-SP1F-ZBPFhAPP, mApp, BACE2
CTCF-EGRF-ZBPFhAPP, BACE2, PS2
CTCF-NRF1hAPP, mApp, BACE1, BACE2, PEN-2
CTCF-EGRF-SP1FhAPP, BACE2, PS2
NRF1-ZBPFhAPP, mApp, BACE2, PEN-2, APH1A
CTCF-EGRFhAPP, mApp, BACE1, BACE2, PS1, PEN-2, APH1A
CTCF-E2FFhAPP, mApp, BACE1, BACE2, NCSTN, APH1A
SP1F-ZBPF-ZBPFBACE1, PS1, PEN-2, APH1A