A Comparative Study of Five Mouse Models of Alzheimer's Disease: Cell Cycle Events Reveal New Insights into Neurons at Risk for Death

Figure 2

Comparison among the mouse lines studied with respect to the presence of cell cycle events (PCNA), tau-phosphorylation (AT8), and beta-amyloid plaque deposition (6E10) in the dorsal raphe. (a) Sagittal section of a wild-type mouse brain indicating the approximate location of the raphe in our preparations. (b) PCNA-positive neurons are illustrated by their appearance in this representative section from the R1.40 mouse model. (c) Minor PCNA immunostaining is seen in wild-type mice as illustrated in this representative micrograph. The insets in both (b) and (c) are representative fields at higher magnification to illustrate the qualities of the cell cycle staining. (d) Quantification of the extent of immunostaining.