A Comparative Study of Five Mouse Models of Alzheimer's Disease: Cell Cycle Events Reveal New Insights into Neurons at Risk for Death

Table 1

Transgenic mouse lines used in this study.

Transgenic lines	Strain	Approach	Mutation	Promoter	Aβ deposits (age of onset)	Age of analysis (this study)
R1.40	B6.129-Tg (APPSw) 40Btla/J	YAC Genomic	Swedish APP	Human APP	14 months	1 yr; 2 yrs
Tg2576	B6 SJL-Tg (APPsw)	cDNA (695)	Swedish APP	Hamster PrP	9–12 months	9–11 months
Tg6799 (5xTg)	B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas/J	Pronuclear coinjection : APP and PS1 transgenes	Swedish, Florida and London APP & human PS1	Murine Thy-1	3 months	6 months
APP8.9	B6.129S2-Tg (APP) 8.9Btla/J	YAC Genomic	Wt huAPP	Human APP	N/A; same as mouse APP expression	14 months
APP/PS1	B6.CgTg (APPswe, PSEN1dE9) 85Dbo/J	cDNA	Swedish/human PS1	Murine PrP	6 months	6-7 months